Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair
نویسندگان
چکیده
منابع مشابه
Novel intrathecal delivery system for treatment of spinal cord injury.
A novel, localized method for potential delivery of therapeutic agents to the injured spinal cord was investigated. The strategy consists of a polymeric drug solution that gels after injection into the subarachnoid space (SAS). By dispersing therapeutic agents in the polymeric solution, a method is provided for localized delivery to the spinal cord. To determine whether intrathecal injection of...
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The failure of long descending pathways to regenerate after spinal cord injury (SCI) is generally attributed to inhibitory proteins associated with the glial scar and myelin, or to the loss of neurons' intrinsic capacity to grow, or both. Here, we describe the use of hydrogels as a novel way to deliver molecules that promote axon growth in the injured CNS of adult rats. This method utilizes an ...
متن کاملRepair of chronic spinal cord injury.
Advances in medical and rehabilitative care now allow the 10-12,000 individuals who suffer spinal cord injuries each year in the United States to lead productive lives of nearly normal life expectancy, so that the numbers of those with chronic injuries will approximate 300,000 at the end of the next decade. This signals an urgent need for new treatments that will improve repair and recovery aft...
متن کاملCurrent trends in spinal cord injury repair.
One of the rapidly prevailing neurological disorders affecting thousands of people per year is spinal cord injury (SCI). Though, great research has been made in recent past to understand thoroughly the molecular bases of the diseases, no fully restorative treatments for SCI are available. However, various rehabilitative, cellular and molecular therapies are being tested in animal models. Some o...
متن کاملUnderstanding the NG2 Glial Scar after Spinal Cord Injury
NG2 cells, also known as oligodendrocyte progenitor cells, are located throughout the central nervous system and serve as a pool of progenitors to differentiate into oligodendrocytes. In response to spinal cord injury (SCI), NG2 cells increase their proliferation and differentiation into remyelinating oligodendrocytes. While astrocytes are typically associated with being the major cell type in ...
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ژورنال
عنوان ژورنال: Theranostics
سال: 2018
ISSN: 1838-7640
DOI: 10.7150/thno.26717